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Rubia Cordifolia (Manjishtha)
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Rubia Cordifolia (Manjishtha)
Rubia Cordifolia or Manjishtha is a climbing plant found in Himalayan region or hilly areas of India. Manjishtha is known as best blood-purifying herb in Ayurveda. It purifies the blood by removing toxins from blood, dissolving obstructions in blood flow and removing stagnant blood. Manjistha is considered to be one of the most valuable herbs in Ayurvedic medicine and has been largely used by physicians since ancient times. The roots are used internally in the treatment of abnormal uterine bleeding, internal and external haemorrhage, bronchitis, rheumatism, stones in the kidney, bladder and gall and dysentery.
Major Chemical Constituents:
Quinones (anthraquinone glycosides), Iridoids (manjistin), Triterpenoids are the major chemical constituents of Rubia cordifolia.
Pharmacological Actions:
Wound healing and bleeding control: 1,2,3
Histological evaluation shows there was a marked infiltration of the inflammatory cells, increased blood vessel formation and enhanced proliferation of cells as a result of treatment with Rubia cordifolia gel and extract. This study thus demonstrates the wound healing activity of ethanolic extract and its gel formulation of the roots of the plant Rubia cordifolia and found to be effective in the functional recovery of the healing of wounds.
Anti oxidant property: 4,5

Rubia cordifolia Linn. (RC) has been reported to possess a significant antioxidant activity in In-vitro studies. A Johrapurkar et al demonstrated the antioxidant activity of alcoholic extract of Rubia cordifolia and its virtue effect on alcohol induced immunosuppression.

Herb Drug interactions:

There are no known Herbal-Drug Interactions

Safety: 5

There are no known safety issues or interactions associated with Manjistha when taken in the recommended doses. The LD­­50 of Rubia cordifolia is found to be more than 2 g/kg.

References:
R. Karodfi, M. Jadhav, R. Rub and A. Bafna. Evaluation of the wound healing activity of a crude extract of Rubia cordifolia L. (Indian madder) in mice. International Journal of Applied Research in Natural Products. 2009; 2(2):12-18
PROTA (Plant Resources Of Tropical Africa), Dyes and Tannins, Vol. 3, page 141, 2005.
Encyclopedia of Herbs and their Uses Dorling Kindersley, London1995.
Tripathi YB, Sharma M, Manickam M. Comparison of antioxidant action of the alcoholic extract of Rubia cordifolia with Rubiadin. Ind J Biochem Biophys. 1998; 35: 313-6.
Johrapurkar A, Zambad SP, Wanjari MM, Umathe SN. In vitro evaluation of antioxidant activity of alcoholic extract of Rubia cordifolia Linn and its influence on ethanol induced immunosuppression. Indian Journal of Pharmacology 2003; 35: 232-236.
 
 
Herbology
 
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
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