Holarrhena antidysenterica (Kutaja)
Holarrhena antidysenterica (Kutaja) Holarrhena antidysenterica is native of tropical Himalayas going up to an altitude of 1100 m. Holarrhena antidysenterica is also found from many forest throughout India including Assam, Uttarpradesh and Travancore. Holarrhena antidysenterica is one of the best drugs for chronic diarrhea. It is also found useful in Amoebic Dysentery, Intestinal & extra-intestinal amoebiasis Bacillary Dysentery, Irritable Bowel Syndrome and Tropical Spru. The bark has astringent, stomachic, febrifugal and tonic property. Major Chemical Constituents: Around 30 alkaloids have been isolated from Holarrhena antidysenterica, mostly from the bark. The principle alkaloid is conessine. Pharmacological Actions: Bleeding Control and Wound Healing activity: 1 Human trial shows that Holorrhena antidysentrica significantly improves wound healing and controls bleeding when studied in Patients with Bleeding Piles. Antibacterial activity: 2 The alkaloids from H. antidysentrica showed strong antibacterial activity against enteropathogenic Escherichia coli (EPEC) strains. Herb Drug interactions: There is no known Herbal-Drug Interactions Safety: No health hazards or side effects are known in conjunction with the proper administration of designated therapeutic dosages. References: • Srikantha Murthy, K.R. Astanga Hrdayam. 5. 2. Varanasi: Krishnadas Academy, 2003. 323-326. Print. • Paranjpe, P, Patki,P and Joshi, N. "Efficacy of an Indigenous Formulation in Patients with Bleeding Piles: a Preliminary Clinical Study." Fitoterapia. 2000; 71: 41-45. • D. Kavitha, P. Shilpa, S. Devraj, and S. Niranjali. Antibacterial and antidiarrhoel effects of alkaloids of Holarrhena antidysenterica WALL, Indian journal of experimental biology. 2004; 42(6): 589-594 • Baldav VS, Sharma RC, Ranka PC, and Chittera MD. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregationin coronary artery disease. Rajasthan Med. J.  1980; 19: 84.