| Introduction: |
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| Jatamansi is native to alpine Himalayas. It is extended to eastward from Kumaon to Sikkim, Bhutan, and Nepal. Jatamansi holds a great important in Ayurvedic and Unani system of medicine. In Ayurveda, the roots of Nardostachys jatamansi have been clinically employed for their anti-ischemic, antioxidant, anticonvulsant, and neuro-protective activities. It has also been used as herbal combinations with other herbs to evaluate depressant activity. |
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| Major Chemical Constituents: |
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| Some of the major chemical constituents of Nardostachys jatamansi are different types of sesquiterpenes and terpenic coumarins. |
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| Pharmacological Actions |
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Sedative activity:1,2,3
Various extracts of Nardostachys jatamansi root were studied to see if it has a sedative effect. The results showed sedative action in rats. Another study showed that jatamansone from Nardostachys jatamansi root exerts tranquilizing activity in mice and monkey. Root powder of N. jatamansi showed sedative action in a clinical study on 24 medical students as evidence by the prolongation of the visual reaction time. |
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Anxiolytic activity:4,5
An experimental model of chronic fatigue syndrome (CFS) was utilized for evaluation of antidepressant and anti-stress effects. The locomotor activity and also the anxiety state in animals were evaluated in an elevated plus maze after CFS in all the four groups. Locomotor activity gradually decreased in stressed control group. Treatment with Nardostachys jatamansi extract significantly reversed both paradigms. There are many well-documented article that shows the anxiolytic activity of Nardostachys jatamansi. |
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| Herb Drug interactions: |
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| There are no known Herb Drug Interactions. |
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| Safety: |
| No health hazards or side effects are known in conjunction with the proper administration of designated therapeutic dosages. |
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| Reference |
| 1 |
Hamied, K.A., Aghara, I.P., Bakshi, V.M., 1962. Pharmacological investigation of Nardostachys jatamansi root. Journal of Scientific & Industrial Research 21C, 100. |
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| 2 |
Arora RB., Singh M., and Saxena YR., 1962b. A biochemical approach to the mechanism of action of jatamansone. Life Sci. No. 11, 571-76 |
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| 3 |
Amin MG., Dixit YB., and Pathak JD., 1961. Reaction time studies in relation to an indigenous drug Nardostachys jatamansi. Antiseptic 58, 583 |
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| 4 |
Lyle N, Gomes A, Sur T, Munshi S, Paul S, Chatterjee S and Bhattacharyya D, The role of antioxidant properties of Nardostachys jatamansi in alleviation of the symptoms of the chronic fatigue syndrome. Behavioral Brain Research 14 September 2009; 202 (2): 285-290. |
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| 5 |
Dhingra D, Goyal PK, Inhibition of MAO and GABA: Probable mechanism for antidepressant-like activity of Nardostachys jatamansi DC. In mice. Indian Journal of experimental Biology. April 2008; 46: 212-218. |
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